Sedating antihistamine abuse
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Antihistamines, in general, have a low potential for addiction if you take them in the recommended doses for a short time. However, if you take the older first generation , sedating antihistamines in higher doses for a prolonged time, you run the risk of physical dependence and addiction, as well as more severe adverse side effects. Most people assume antihistamines are of no concern because of their easy access in over-the-counter allergy, cough, and cold medicines and sleep aids. According to a review in Allergy , the older, first generation , sedating antihistamines, developed in the s to s, penetrate the central nervous system CNS. This is what gives them a potential for abuse and addiction. The few cases of antihistamine addiction reported in the medical literature are mainly on diphenhydramine DPH.
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Antihistamines: Using Them Safely
Antihistamines are medicines to treat allergic reactions to pollen, dust, pet dander, foods, and drugs. Antihistamines are found in many different forms for children and adults: Finding the best antihistamine for your symptoms can take a while. In the meantime, never take too much! Are you are one of the 50 million people in the U.
By Mark D. Antihistamine medications block or reduce histamine-mediated effects at one of four identified histamine receptors see Table 1 below. Currently the only FDA-approved histamine antagonist medications block the effects of histamine at H1 or H2 receptor sites. These include the first-generation H1 antagonists, or sedating antihistamines eg, diphenhydramine, chlorpheniramine , and second-generation H1 receptor blockers, or nonsedating antihistamines eg, loratadine, cetirizine.
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